Pharmacological preparations comprising human pluripotent hemato

Details Pharmacological preparations comprising human pluripotent hemato Pharmacological preparations comprising human pluripotent hemato

1995-06-07

1997-09-23

Jagannathan, Vasu S.

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 530350, 530395, 435 695, 435 691, A61K 3819, C07K 1453

Patent

active

056701462

ABSTRACT:
Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5.times.10.sup.8 U/mg protein.

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