Intracellular trapping of therapeutics or tracer agents

Details Intracellular trapping of therapeutics or tracer agents Intracellular trapping of therapeutics or tracer agents

1982-11-12

1984-08-21

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

260112R, 536 11, 424 9, A61K 4300, A61K 4900

Patent

active

044669518

ABSTRACT:
A method is provided for trapping therapeutic or tracer agents within cells to maximize their therapeutic effect or detectability. Primary amine containing therapeutic or tracer agents are bound by reductive deamination to the active carbonyl of cellobiose. The resulting adduct is attached to a targeting agent for introduction into a selected cell. Due to the cellobiose, the adduct remains trapped within the cell to maximize therapeutic or tracer activity. Novel adducts and targeting agent-adduct conjugates are disclosed. A new double label method for measuring protein metabolism is also disclosed.

REFERENCES:
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4157323 (1979-06-01), Yen et al.
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4386026 (1983-05-01), Ponpipom et al.
Pittman et al., Biochem. J., vol. 212, (1983), pp. 791-800.

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