Platinum-diamine complexes, a process for the preparation thereo

Details Platinum-diamine complexes, a process for the preparation thereo Platinum-diamine complexes, a process for the preparation thereo

1982-02-26

1984-08-21

Sneed, Helen M. S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424287, C07F 1500

Patent

active

044669240

ABSTRACT:
Platinum diamine complexes of the general formulae ##STR1## wherein R.sub.1 and R.sub.2 independently from each other are a hydrogen atom or a substituted or unsubstituted alkyl, cyclo-alkyl, aryl or aralkyl group, while R.sub.1 and R.sub.2 may be together a substituted or unsubstituted cyclo-alkyl group, R.sub.3 and R.sub.4 independently of each other are a hydrogen atom or a substituted or unsubstituted alkyl, aryl or aralkyl group and X is a chlorine, bromine or iodine atom, a sulphate radical, a substituted or unsubstituted carboxylate rest like an acetate or substituted acetate radical, an oxalate, malonate, hydroxymalonate or otherwise substituted malonate group or a carboxylate group, the group Y, independently from X is a chlorine, bromine or iodine atom, a hydroxyl group, a nitrate group of a carboxylate group have been found to exhibit antitumor activity together with little or none kidney toxicity and are thus of interest as a medicament.
Processes for the preparation of the platinum complexes are described and exemplified.

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