Process for preparing spray-dried powders containing a water-sol

Details Process for preparing spray-dried powders containing a water-sol Process for preparing spray-dried powders containing a water-sol

1984-10-23

1986-08-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514960, A61K 31365

Patent

active

046056661

ABSTRACT:
The subject invention relates to a process for preparing a powder containing a water-soluble vitamin which is directly compressible into a tablet prepared by spray drying (a) an aqueous slurry of a water-soluble vitamin and a binder; (b) preferably an adsorbent; and (c) a lubricant. Particularly useful water-soluble vitamins are ascorbic acid, sodium ascorbate, and calcium ascorbate. The unique feature of the process is that the lubricant is spray dried along with the other components.
The invention also relates to powders prepared by this process. The powders are directly compressible into tablets and will not demix.

REFERENCES:
patent: 3266992 (1966-08-01), de Jong
patent: 3293132 (1966-12-01), Stoyle et al.
patent: 3396226 (1968-08-01), Cavalli et al.
patent: 3852421 (1974-12-01), Koyanagi et al.
patent: 4036948 (1977-07-01), Kitamori et al.
patent: 4352821 (1982-10-01), Doran et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4533674 (1985-08-01), Schmidt et al.
Chem. Abst. 99, 218464(v), (1983)-Velilcova et al.

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