Leader sequence inducing a post-translational modification of po

Details Leader sequence inducing a post-translational modification of po Leader sequence inducing a post-translational modification of po

1988-07-05

1993-06-08

Martinell, James

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 935 47, 935 49, C12N 1531

Patent

active

052181014

ABSTRACT:
The method by which polypeptides having residues other than the 20 common amino acids are made is established. A leader peptide sequence, and its gene, are identified which induce or assist post-translational modifications of Cys, Thr and Ser in prokaryotes. The leader sequence may be used to induce the presence of covalent bonding sites in polypeptides and can be expressed by either naturally occurring or artificial means.

REFERENCES:
patent: 4716115 (1987-12-01), Gonzalez et al.
Hurst et al.; Can. J. Microbiol. 17: 1379 (1971).
Nishio et al.; Biochem. Biophys. Res. Comm. 116: 751 (1983).
Banerjee et al.; J. Biol. Chem. 263: 9508 (1988).

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