Condensed quinoline system N-glycosides

Details Condensed quinoline system N-glycosides Condensed quinoline system N-glycosides

1991-09-16

1993-06-08

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 42, 536 187, 536 292, 546 70, A61K 3147, A61K 3170, C07H 1524

Patent

active

052179613

ABSTRACT:
The present invention provides condensed quinoline compounds represented by the following general formula (I): ##STR1## in which Z is NH, X is hydrogen, L is lower alkoxy, M is NHQ, Q is --SO.sub.2 CH.sub.3, Y is --NHR, and R is: ##STR2## These compounds are effective for inhibiting KB-cell growth and prolongation of the life span of mice implanted with tumor P-388.

REFERENCES:
patent: 4826850 (1989-05-01), Yamato
Journal of Medicinal Chemistry, vol. 30, 1987 pp. 1576-1581, G. W. Rewcastle, et al.

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