Composition and treatment with biologically active peptides and

Details Composition and treatment with biologically active peptides and Composition and treatment with biologically active peptides and

1991-10-29

1993-06-08

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 514 21, 530324, 530325, 530326, 530350, 530824, A61K 3702, C07K 710

Patent

active

052179567

ABSTRACT:
An amphiphilic ion-channel forming peptide and a toxic anion are employed as a pharmaceutical.

REFERENCES:
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Hoffman et al., "A novel peptide designated PYLa and its precursor as predicted from cloned mRNA of Xenopus laevis skin", The EMBO Journal, 2:711-714, 1983.
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Giovannini et al., "Biosynthesis and degratdation of peptides derived form Xenopus laevis prohormones," Biochem J. 243:113-120, 1987.
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Selsted, et al, "Primary Structures of Three Human Neutrophil Defensins," J. Clin. Invest., vol. 76, pp. 1436-1439 (1985).
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Ooi, et al., "A 25-kDa Nh2-terminal Fragment Carries All the Antibacterial Activities of the Human Neutrophil 60-kDaBactericidal/Permeability-increasing Protein," J. Biol. Chem., vol. 262, pp. 14891-14894 (1981).
Henkart, et al, "Cytolytic Activity of Purified Cytoplasmic Granules From Cytotoxic Rat Large Granular Lymphocyte Tumors," J. Exp. Med., 160:75 (1984).
Podack, et al., "Cytolytic T Cell Granules," J. Exp. Med. 160:695 (1984).

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