Monoclonal antibodies recognizing parathyroid hormone-like prote

Details Monoclonal antibodies recognizing parathyroid hormone-like prote Monoclonal antibodies recognizing parathyroid hormone-like prote

1988-12-30

1993-06-08

Doll, John J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

53038824, 5303911, 5303913, 435 7021, 4351722, C12N 520, C12N 1502, C07K 1528, C12P 2108

Patent

active

052178960

ABSTRACT:
This invention provides a monoclonal antibody which specifically forms a complex with amino acids 1-87 of PTHLP which does not form a complex with amino acids 1-34 of PTHLP, and which forms a complex with the epitope to which any of the monoclonal antibodies produced by the hybridomas 212-10.7, (ATCC Accession No. HB9930), 199-999 (ATCC Accession No. HB9929), 199-278 (ATCC Accession No. HB9931), is directed.
This invention further provides methods of detecting PTHLP and of diagnosing and treating humoral hypercalcemia of malignancy.

REFERENCES:
Mangin, M. et al., (1988) Proc. Natl. Acad. Sci. USA 85: 597.
Burtis, W. J. et al., (1987) J. Biol. Chem. 262:7157.
Moseley, J. M. et al., (1987) Proc. Natl. Acad. Sci. USA 84: 5048.
Nissenson, R. A. et al., (1988) J. Biol. Chem. 263: 12866.
Suva, L. J. et al., (1987) Science 237: 893.
Weir et al. Endocrinology 123(6):2744-2751 1988.
Maurer et al. Methods in Enzymology vol. 70 pp. 49-70, 1980.
Morrison, Science 229:1202-1207, 1985.
Buck et al. in Kennett et al Eds. Monoclonal Antibodies and Functional Cell Lines Plenum Press, 1984.

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