Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their phar

Details Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their phar Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their phar

1991-06-17

1992-10-20

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47108

Patent

active

051571609

ABSTRACT:
A compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## in which Z is a heterocyclic group ##STR2## in which Q represents a 3-membered divalent residue completing a 5-membered aromatic ring and comprises one or two heteroatoms selected from oxygen, nitrogen and sulphur, or three nitrogen atoms, any amino nitrogen being substituted by a C.sub.1-2 alkyl, cyclopropyl or propargyl group, and any ring carbon atom being optionally substituted by a group R.sub.1 ; or a group ##STR3## in which A.sub.1, A.sub.2 and A.sub.3 complete a 5-membered aromatic ring and A.sub.1 is oxygen or sulphur, one of A.sub.2 and A.sub.3 is CR.sub.2 and the other is nitrogen or CR.sub.3, or A.sub.2 is oxygen or sulphur, one of A.sub.1 and A.sub.3 is CR.sub.2 and the other is CR.sub.3 ; and R.sub.1, R.sub.2 and R.sub.3 are independently selected from hydrogen, halogen, CN, OR.sub.4, SR.sub.4, N(R.sub.4).sub.2, NHCOR.sub.4, NHCOOCH.sub.3, NHCOOC.sub.2 H.sub.5, NHOR.sub.4, NHNH.sub.2, NO.sub.2, COR.sub.4, COR.sub.5, cyclopropyl, C.sub.2-5 straight chain alkenyl, C.sub.2-5 straight chain alkynyl or C.sub.1-5 straight chain alkyl optionally terminally substituted with OR.sub.4, N(R.sub.4).sub.2, SR.sub.4, CO.sub.2 R.sub.4, CON(R.sub.4).sub.2 or one, two or three halogen atoms, in which each R.sub.4 is independently hydrogen or C.sub.1-3 alkyl and R.sub.5 is OR.sub.4, NH.sub.2 or NHR.sub.4 ; or in which Z is a group --C(R.sub.7).dbd.NR.sub.6 in which R.sub.6 is a group OR.sub.8, where R.sub.8 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, a group OCOR.sub.9 where R.sub.9 is hydrogen or R.sub.8, or a group NHR.sub.10 or NR.sub.11 R.sub.12 where R.sub.10, R.sub.11 and R.sub.12 are independently C.sub.1-2 alkyl and R.sub.7 is hydrogen or C.sub.1-4 alkyl, subject to the proviso that when R.sub.6 is a group OCOR.sub.9 or NHR.sub.10, R.sub.7 is C.sub.1-4 alkyl. The compounds are potentially useful in the treatment of diseases of the nervous system.

REFERENCES:
patent: 4971975 (1990-11-01), Hadley et al.

Affiliated with

Also associated with

Rating

Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their phar does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their phar, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain 5-substituted-1-azabicyclo[3.1.1]heptanes and their phar will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-193339