Medical composition for injection containing a spergualin as act

Details Medical composition for injection containing a spergualin as act Medical composition for injection containing a spergualin as act

1986-01-09

1987-12-01

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514 2, 514644, A61K 3116

Patent

active

047105178

ABSTRACT:
The present invention relates to a stable medical composition for injection containing (1) a Spergualin of the formula: ##STR1## [wherein R is ##STR2## --(CH.sub.2).sub.6 --, --(CH.sub.2).sub.4 --CH.dbd.CH--, ##STR3## (wherein R' is a lower alkyl group having 1 to 4 carbon atoms), --(CH.sub.2).sub.8 --, or ##STR4## or a salt thereof and (2) at least one stabilizer selected from the group consisting of mannitol, maltose, dextran, lactose, cyclodextrin, gelatin, chondroitin sulfate, and human serum albumin; when R is ##STR5## mannitol is expected. A spergualin is useful as cancer control agents and immunomodulators.

REFERENCES:
patent: 4416899 (1983-11-01), Umezawa et al.
patent: 4430346 (1984-02-01), Umezawa et al.
patent: 4518532 (1985-05-01), Umezawa et al.
patent: 4525299 (1985-06-01), Umezawa et al.
patent: 4529549 (1985-07-01), Umezawa et al.
The Merck Index, 9th ed., Merck and Co., Rahway, N.J., 1976, entry nos. 4217, 5192, 5575.

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