Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-03-14
1987-12-01
Schofer, Joseph L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549292, A61K 3135
Patent
active
047105135
ABSTRACT:
6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
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Cragoe, Jr. Edward J.
Hoffman William F.
Novello Frederick C.
Willard Alvin K.
DiPrima Joseph F.
Merck & Co. , Inc.
Nicholson William H.
Reddick J. M.
Schofer Joseph L.
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