Antibacterial coated medical implants

Details Antibacterial coated medical implants Antibacterial coated medical implants

1992-03-11

1993-06-08

Isabella, David

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

604265, A61F 202

Patent

active

052174930

ABSTRACT:
An implantable medical device having long lasting resistance to staphylococcal biofilm colonization is provided. Implantable medical devices such as catheters, shunts, prosthesis, pacemakers, etc. are susceptible to colonization by biofilm adherent microorganisms, especially staphylococci. While systemic staphylococcal infections are effectively treated by many antibiotics, vancomycin being the antibiotic of choice, this same bacteria when encased in biofilm adhering to indwelling medical devices is generally resistant to antibiotic treatment. By the present invention, the combination of rifampin and minocycline or the combination of rifampin and novobiocin when coated on the surfaces of implantable medical devices unexpectedly provides superior antibacterial activity against staphylococcal biofilm colonization on the coated surface of indwelling medical devices.

REFERENCES:
patent: 4107121 (1978-08-01), Stoy
patent: 4678660 (1987-07-01), McGary et al.
patent: 4749585 (1988-06-01), Greco et al.
patent: 4846844 (1987-07-01), DeLeon et al.
patent: 4879135 (1989-11-01), Greco et al.
patent: 4895566 (1990-01-01), Lee
patent: 4915694 (1990-04-01), Yamamoto et al.
patent: 4917686 (1990-04-01), Bayston et al.
patent: 4952419 (1990-08-01), DeLeon et al.
patent: 5013306 (1991-05-01), Solomon et al.
Raad et al., 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract No. 31, (Sep. 29, 1991).
Darouiche et al., "Eradication of Colonization by Methicillin-Resistant Staphylococcus aureus by Using Oral Minocycline-Rifampin and Topical Mupirocin", Antimicrobial Agents and Chemotherapy 35:1612-1615 (Aug. 1991).
Kamal et al., "Reduced Intravascular Catheter Infection by Antibiotic Bonding", Journal of American Medical Association 265:2364-2368 (May 8, 1991).
Raad et al., "Alternative Agents Against Staphylococcal Isolates Causing Catheter Related Bacteremia (CRB) in Cancer Patients", 90th Annual Meeting of the American Society for Microbiology, Abstract No. A149 (May 13, 1990).
Farber et al., "Staphylococcus epidermidis Extracted Slime Inhibits the Antimicrobial Action of Clycopeptide Antibiotics", Journal of Infectious Diseases 161:37-40 (1990).
Segreti et al., "In Vitro Activity of Minocycline and Rifampin Against Staphylococci", Diagn. Microbiol. Infect. Dis. 12:253-255 (1989).
Sherertz et al., "Efficacy of Dicloxacillin-Coated Polyurethane Catheters in Preventing Subcutaneous Staphylococcus aureus Infection in Mice", Antimicrobial Agents and Chemotherapy 33:1174-1178 (Aug. 1989).
Evans et al., "Effect of Vancomycin Hydrochloride on Staphylococcus epidermidis Biofilm Associated with Silicone Elastomer", Antimicrobial Agents and Chemotherapy 31:889-894 (Jun. 1987).
Yourassowsky et al., "Combination of Minocycline and Rifampicin Against Methicillin-and Gentamicin-Resistant Staphylococcus aureus, ", Journal of Clinical Pathology 34:559-563 (1981).
Zinner et al., "Antistaphylococcal Acivity of Rifampin with Other Antibiotics", Journal of Infectious Diseases 144:365-371 (Oct. 1981).

Affiliated with

Also associated with

Rating

Antibacterial coated medical implants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibacterial coated medical implants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibacterial coated medical implants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1930757