Method for treating hypercalcemia using salts of TNCA

Details Method for treating hypercalcemia using salts of TNCA Method for treating hypercalcemia using salts of TNCA

1993-09-17

1995-02-21

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3138

Patent

active

053915674

ABSTRACT:
Malignancy-induced hypercalcemia is treated with thionapthene-2-carboxylic acid (TNCA) and the pharmaceutically acceptable salts thereof. The treatment is also effective in tumor bearing hosts even before there is significant abnormal serum calcium levels. There is no "escape" from the hypocalcemic effects of these compounds as with e.g., calcitonin. The useful dosage in humans for TNCA itself ranges from about 1 to about 60 mg/kg/day preferably from about 2 to about 30 mg/kg/day and more preferably from about 5 to about 20 mg/kg/day (20 mg is approximately 0.106 mmol) Orally administered TNCA or salts thereof, is a much desired and obviously clinically advantageous mode of administering compounds to control or ameliorate hypercalcemia.

REFERENCES:
patent: 4101668 (1978-07-01), Samour et al.
patent: 4125621 (1978-11-01), Samour et al.
patent: 4185108 (1980-01-01), Samour et al.
patent: 4434163 (1984-02-01), Lombardino
Raisz et al, Calcif Tissue Int. (1985) 37:556-559, "Effects of Thionapthene 2-Carboxylic Acid and Related Compounds on Bone Resorption in Organ Culture".
Johannesson et al, Endocrinology, vol. 117, No. 4 (1985), pp. 1508-1511, "Thionapthene-2-Carboxylic Acid: A New Antihypercalcemic Agent".

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