Regulation of expression

Details Regulation of expression Regulation of expression

1989-11-22

1992-10-20

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1700

Patent

active

051571153

ABSTRACT:
The inhibition or control of expression of IL-2 or IL-2.alpha. genes, and the inhibition or control of fundamental cellular processes responsible for retroviral replication, in particular HIV-I and HTLV-I DNA molecules, are disclosed. The invention is directed to nucleic acids or nucleic acid compositions which competitively bind regions of the IL-2 or IL-2.alpha. genes corresponding to their respective transcription factors. DNA or RNA fragments spanning the following regions in the IL-2 gene are shown to be effective; -195 to -204; -115 to -164; and -165 to -222. DNA or RNA fragments spanning the following regions in the IL-2.alpha. gene are shown to be effective: -62 to -71; and -32 to -86. Compositions comprising combinations of these fragments are also disclosed.

REFERENCES:
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T. Fujita, et al., "Regulation of human interleukin-2 gene" Cell, 46:401-407, 1986.
Bohnlein et al., The Same Inducible Nuclear Proteins Regulates Mitogen Activation of Both the Interleukin-2 Receptor-Alpha Gene and Type 1 HIV, Cell, 53:827-836 (1988).
Cross et al., Regulation of the Human Interleukin-2 Receptor.alpha. Chain Promoter: Activation of a Nonfunctional Promoter by the Transactivator Gene of HTLV-1, Cell, 49:47-56 (1987).
Leung et al., HTLV-1 Transactivator Induces Interleukin-2 Receptor Expression Through An NF-kB-Like Factor, Nature, 333:776-778 (1988).
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