Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D26106

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055592422

ABSTRACT:
A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated.

REFERENCES:
patent: 5409946 (1995-04-01), Garvey et al.
CA 123:9432 Method of . . . isoxazoles. Lin et al., 1994.
CA 123:55872 Isoxazole, . . . function. Garvey et al., (1967).

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