Aminocyclitol antibiotics

Details Aminocyclitol antibiotics Aminocyclitol antibiotics

1975-02-18

1976-08-03

Demers, Arthur P.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260563C, 260563P, 195 96, 536 17, C07C 8738

Patent

active

039729303

ABSTRACT:
Aminocyclitol analogs of gentamicin C.sub.1, C.sub.2 and C.sub.1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an .omega.-amino-.alpha.-hydroxy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbohydrates, a source of assimilable nitrogen, essential salts and an added aminocyclitol with a mutant of Micromonospora purpurea and acylating the product with an ester of an .omega.-(N-benzyloxycarbonyl)amino-.alpha.-hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.

REFERENCES:
patent: 3112345 (1963-11-01), Stanbury
Peck et al., J. Am. Chem. Soc. 68, (1946), pp. 776-781.
Shier et al., J. Antibiotics, vol. 26, (1973), pp. 551-561.

Affiliated with

Also associated with

Rating

Aminocyclitol antibiotics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminocyclitol antibiotics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminocyclitol antibiotics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1929179