Pharmaceutical formulations of cyclic urea type compounds

Details Pharmaceutical formulations of cyclic urea type compounds Pharmaceutical formulations of cyclic urea type compounds

1994-03-09

1996-09-24

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540492, 424455, 424498, A61K 3155, A61K 966, A61K 950, C07D24304

Patent

active

055591108

ABSTRACT:
Compositions comprising a cyclic urea type compound in a liquid or solid vehicle comprising a fatty acid ester of glycerol, or a fatty acid ester of polyethylene glycol, or a mixture thereof, wherein said vehicle has an hydrophil-lipophil balance of at least about 10, and, optionally, other excipients are described. The compositions are useful for providing good systemic absorption of the cyclic urea compounds when administered enterally, especially orally. The subject compounds and compositions are useful for treating viral infections, particularly HIV infection, in a mammal.

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Cavanak and Sucker, Prog. Allergy, 38:65-72 (1986).
Chiou and Riegelman, J. Pharm. Sci., 60:1376-1380 (1976).
Astl et al., "Chemical Tradename Dictionary," VCH Publishers, 1993. pp. 200, 88, & 156.

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