Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-05-19
1996-09-24
Cunningham, Thomas M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435724, 4241851, 4241931, 530300, 530326, 530868, 514 2, 514 13, C12N 506, C07K 700, A61K 3810
Patent
active
055590284
ABSTRACT:
The subject disclosure relates to the identification of mutations in the I.sub.i protein which result in an alteration of the endoprotease cleavage pattern of the mutant I.sub.i as compared with the endoprotease cleavage pattern of the wild type product. Methods for the identification of such mutants, and the mutants themselves are useful for the identification of classes of compounds to be further tested for immunomodulatory activity. A specific example of such a use is the screening of small organic compounds for the ability to bind to an intermediate in the I.sub.i endoprotease processing pathway. An small organic molecule having the ability to bind to such an intermediate can be further screened for the ability to modulate antigen presentation. The present invention also relates to the identification of immunomodulatory peptides. Peptides which either enchance or inhibit MHC Class II-restricted presentation of antigenic peptides are identified.
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Antigen Express, Inc.
Cunningham Thomas M.
Farrell Kevin M.
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