Disease diagnosis by detection of shed normal tissue antigens

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4351722, 43524027, 436520, 436526, 436531, 436534, 436548, 436804, 436813, G01N 33535, G01N 33545, G01N 33574, G01N 33577

Patent

active

047313269

ABSTRACT:
Methods are provided for the detection of proximal convoluted tubule causing diseases or kidney harmful drug monitoring by detecting the presence of shed normal proximal tubule associated antigens in a body fluid such as urine. The preferred embodiment employs an ELISA sandwich format wherein one monoclonal antibody specific for a first epitopic site on said antigen is immobilized on a solid phase and a second antibody, specific for a second epitopic site on said antigen is directly or indirectly labeled.

REFERENCES:
patent: 4376110 (1983-03-01), David
patent: 4447545 (1984-05-01), DeFazio et al.
patent: 4471058 (1984-09-01), Smith
patent: 4474892 (1984-10-01), Murad
patent: 4650756 (1987-03-01), Old
H. J. Sachse et al., "Development of a Radioimmunoassay for a High Molecular Mass Tubular Antigen in Urine-Its Application for Early Detection of Tubular Damage", Clinica Chimica Acta, 110:91-104 (1981).
J. M. Wellwood et al., "Urinary N-Acetyl-.beta.-D-Glucosaminidase Assays in Renal Transplant Recipients", Transplantation, pp. 396-400, (1978).
A. W. Mondorf et al., "Brush Border Enzymes and Drug Nephrotoxicity" Acute Renal Failure, Marcel Dekker, New York (1983).
D. Pierard et al., "Monoclonal Antibodies as Tools for Kidney Damage Diagnosis", Clinical Assays, vol. 31:1047-1050 (1983).
W. P. Schrader et al., "Immunoassay of the Adenosine Deaminase Complexing Proteins of Human Tissue and Body Fluids", The Journal of Biological Chemistry, vol. 254, 23:11958-63 (1979).
K. Jung et al., "Influence on pH on the Activity of Enzymes in Urine at 37.degree. C.", Chem. 25,965 (1980) Abstract.
M. D. Bastable, ".beta..sub.2 -Microglobulin in Urine: Not Suitable for Assessing Renal Tubular Function", Clinical Chemistry, vol. 29, 5:996-997 (1983).
R. Ueda et al., Proc. Nat'l Acad. Sci. U.S.A., 78, 5122-5126 (1981).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Disease diagnosis by detection of shed normal tissue antigens does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Disease diagnosis by detection of shed normal tissue antigens, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Disease diagnosis by detection of shed normal tissue antigens will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1926400

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.