2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-p

Details 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-p 2-(substituted imino)-6-aryl-3,6-dihydro-4-substituted-1,5(2H)-p

1986-02-24

1987-08-25

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544295, 544296, 544331, 544332, 544 2, 544 3, 544 5, 544 7, 544 8, 544 55, 544 581, 544 585, 544 586, 544 63, 544 65, 544 66, 544 67, 544 72, 544 82, 544 96, 544111, 544112, 544113, 544114, 544120, 544121, 544122, 544123, 544179, 544180, 544182, 544238, C07D23922

Patent

active

046894144

ABSTRACT:
Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is alkyl, cycloalkyl, aryl, heterocyclo, --(CH.sub.2).sub.n --Y.sub.2, --(CH.sub.2).sub.p --Y.sub.3 or halo substituted alkyl;

REFERENCES:
patent: 4532248 (1985-07-01), Franckowiak et al.
J. Org. Chem., vol. 50, pp. 4227-4230, "Synthesis of Novel Dihydropyrimidines and Tetrahydropyrimidines", Cho et al., (1985).
Medicinal Chemistry, Burger edit., 2nd ed., 1960, pp. 565-571, 579-581, and 600-601.
Hof, J. Cardiovas. Pharmacol., 6, pp. 399-406 (1984).
Hof, J. Cardiovas. Pharmacol., 6, pp. 407-416 (1984).

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