5-substituted octahydroindolizine analgesics compounds and 7-ket

Details 5-substituted octahydroindolizine analgesics compounds and 7-ket 5-substituted octahydroindolizine analgesics compounds and 7-ket

1986-02-04

1987-08-25

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544180, 544216, 544238, 544242, 544335, 544336, A61K 3140, C07D47104

Patent

active

046893296

ABSTRACT:
Octahydroindolizidines and corresponding ketones of the formulae (I) and (II): ##STR1## where A is a 3-7 carbon or hetero-containing ring, R.sup.1 is a substituent, n is 0-6 and x is 0-3. Also, pharmaceutical compositions for treating pain containing (I) or (II) and methods for synthesis and use as well as novel intermediates in the synthesis. A

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M. E. Rogers et al.; the Journal of Medicinal Chem., vol. 18, No. 11, pp. 1126-1130 (1975).
F. Lions et al.; Proc. Royal Soc., N. S. Wales 73, pp. 240-252 (1940).

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