Serine protease inhibitors

Details Serine protease inhibitors Serine protease inhibitors

1991-07-01

1992-10-20

Chan, Y. Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 530324, 530325, 530326, 530327, A61K 3702, A61K 3764, C07K 710, C07K 708

Patent

active

051570190

ABSTRACT:
Novel peptides which exhibit inhibitory activity toward serine proteases and methods for preparing and using same are disclosed. In one aspect, the present invention provides peptides comprising a generic inhibitory core having a functional site recognition sequence fused to the N-terminus. The functional site recognition sequence is adapted to provide enhanced selectivity and/or potency for a target protease.

REFERENCES:
patent: 4455290 (1984-06-01), Olexa et al.
patent: 4485100 (1984-11-01), Hochstrasser et al.
Chandra et al., Biochemical and Biophysical Research Communications, vol. 103, No. 2, pp. 751-758 (1981).
Chandra et al., Biochemistry, vol. 22, No. 22, pp. 5055-5061 (1983).
Ragg, Nucleic Acids Research, vol. 14, No. 2, pp. 1073-1087, (Jan. 24, 1986).
Carrell et al., Biochemical and Biophysical Research Communications, vol. 91, No. 3, pp. 1032-1037 (1979).
Kurachi et al., Proc. Natl. Acad. Sci. U.S.A., vol. 78, No. 11, pp. 6826-6830 (1981).
Morii et al., The Journal of Biological Chemistry, vol. 258, No. 21, pp. 12749-12752 (1983).
Rudinger, University Park Press, (Parsons ed.), Baltimore, pp. 1-7 (1976).
Carrell et al., Biochem. and Biophys. Res. Comm., 91:1032 (1979).

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