Novel nitrosourea derivatives and process for their production

Details Novel nitrosourea derivatives and process for their production Novel nitrosourea derivatives and process for their production

1981-02-23

1982-06-15

Waltz, Thomas A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564 33, 568949, 562553, 562597, C07C1271

Patent

active

043352472

ABSTRACT:
The specification describes a nitrosourea derivative having the general formula: Cl--(CH.sub.2).sub.2 --N(NO)CO--NHR, wherein --NHR represents a 2-(1,3,4-thiadiazolyl)amino group, an amino residue of a neutral .alpha.-amino acid, or an amino residue of a neutral .alpha.-amino acid whose carboxyl group is amidated with 2-(1,3,4-thiadiazolyl)amine, or a pharmaceutically acceptable acid addition salt thereof. The above nitrosourea derivative and its salt are useful as antitumor drugs. The above nitrosourea derivative may be prepared either by nitrosating a urea derivative of the general formula: Cl--(CH.sub.2).sub.2 NHCONHR or by reacting N-(2-chloroethyl)-N-nitrosocarbamic acid or a reactive derivative thereof with an amino compound of the general formula: R--NH.sub.2.

REFERENCES:
patent: 3859277 (1975-01-01), Murakami et al.
patent: 4028410 (1977-06-01), Yanko et al.
patent: 4039578 (1977-08-01), Suami
patent: 4148921 (1979-04-01), Suami
patent: 4175081 (1979-11-01), Driscoll
Chemical Abstract, vol. 88, #83362k, Masahito et al., 1977.
Chemical Abstract, vol. 83, #58706q, Zhelyakov, 1974.
Chemical Abstract, vol. 81, #77156k, Lyh et al., 1974.

Affiliated with

Also associated with

Rating

Novel nitrosourea derivatives and process for their production does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel nitrosourea derivatives and process for their production, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel nitrosourea derivatives and process for their production will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1919982