Polyribonucleotides capable of promoting the genesis of leucocyt

Details Polyribonucleotides capable of promoting the genesis of leucocyt Polyribonucleotides capable of promoting the genesis of leucocyt

1979-07-03

1982-06-15

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2102

Patent

active

043352391

ABSTRACT:
The invention relates to new medicaments useful for the treatment of leucocyte and platelet deficiencies, which medicaments are polyribonucleotides prepared by degradation of the ribosomic ribonucleic acids extracted from micro-organisms or from animal organs and are formed of simple chains or "RNA fragments" comprising about 20 to 80 ribonucleotide units, the overall ratio of purine bases (G+A) to pyrimidine bases (C+U) being between 1.0 and 2.5.
The invention also relates to a process for the preparation of these polyribonucleotides by scission of the ribosomic ribonucleic acids extracted from suitable micro-organisms, by means of a ribonuclease or of a chemicl reagent such as an alkali metal base.

REFERENCES:
patent: 3457254 (1966-10-01), Yano et al.
The Chemistry of Nucleoside and Nucleotides, A. M. Michelson, Academic Press, London, 1963, pp. 339-342.

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