Immunobiologically-active linear peptides and method of identifi

Details Immunobiologically-active linear peptides and method of identifi Immunobiologically-active linear peptides and method of identifi

1998-06-12

2000-05-30

Carlson, Karen Cochrane

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

530300, C07K 1400

Patent

active

060701269

ABSTRACT:
The present invention relates to identifying protein epitopes and more particularly to a novel method for identifying, determining the location, optimal length of amino acid residues and immunobiological potency of protein epitopes by applying a custom negative cosine function fit algorithm to a protein hydropathy scale. This fit analysis is supplemented with experimental immunobiological data. The amino acid sequence of the protein epitopes of the present invention exhibit a hydrophobic-hydrophilic-hydrophobic hydropathy pattern of an approximately fixed length in a given protein.

REFERENCES:
patent: 4554101 (1985-11-01), Hopp
patent: 5807978 (1998-09-01), Kokolus et al.
Abramowitz, M., Stegun, I.,(eds) "Handbook of Mathematical Functions", National Bureau of Standards Applied Mathematics Series, #55, 71-79, 1964.
Atherton et al., "Peptide Synthesis", Tetrahedron, 44:843-857, 1988.
Barany et al., Solid-Phase Peptide Synthesis, The Peptides, 2: 1-284, 1988.
Fynan et al., "DNA vaccines: Protective immunization by parenteral, mucosal, and gene-gun inoculations", Proc. Natl. Acad. Sci. USA, 90:11478-11482, Dec. 1993.
Henttu et al., "cDNA Coding for the Entire Human Prostate Specific Antigen Shows High Homologies to the Human Tissue Kallikrein Genes", Biochemical and Biophysical Research Communication, 160: 903-910, 1989.
Hopp et al., "Prediction of protein antigenic determinants from amino acid sequences", Proc. Natl. Acad. Sci. USA, 78(6):3824-3828, Jun. 1981.
Kyte et al., "A Simple Method for Displaying the Hydropathic Character of a Protein", J. Mol. Biol., 157:105-132, 1982.
Pellequer et al., "Predicting Location of Continuous Epitopes in Proteins from Their Primary Structure", Methods in Enzymology, 203:176-201, 1991.
Robinson, HL, "DNA Vaccines", (Abstract) Seminars in Immunology, 9(5) 271, Oct. 1997.
Rosenblum et al., "Amino Acid Sequence Analysis, Gene Construction, Cloning, and Expression of Gelonin, a Toxin Derived from Gelonium multiflorum", J. Interferon and Cytokine Research, 15:547-555, 1995.

Affiliated with

Also associated with

Rating

Immunobiologically-active linear peptides and method of identifi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunobiologically-active linear peptides and method of identifi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunobiologically-active linear peptides and method of identifi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1918095