2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkyn

Details 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkyn 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkyn

1990-01-29

1991-09-17

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514423, 514424, 548530, 548543, C07D20724, A61K 3140

Patent

active

050495771

ABSTRACT:
Antihypercholesterolemic activity has been discovered in compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: Z is ##STR2## X is lower alkyl, lower alkenyl, or lower alkenyl; R.sup.1 is hydrogen, alkyl, alkenyl, aryl, alkylaryl, or substituted aryl having one or more substituents; and

REFERENCES:
patent: 3975399 (1976-08-01), DeFranco et al.
patent: 4452807 (1984-06-01), Aschwanden et al.
patent: 4461906 (1984-07-01), Aschwanden et al.
patent: 4800212 (1989-01-01), Evans et al.
Mauger, A. B., J. Org. Chem. 46 (1981) 1032-1035.
Cocolas, G. H. et al., J. Am. Chem. Soc. 79 (1957) 5203-5205.
Delaney, N. G., et al., J. Am. Chem. Soc. 104 (1982) 6635-6641.
Hartwig, W., et al., J. Org. Chem., 52 (1987) 4352-4358.
Kende, A. S. et al., Tetrahedron Letters, 29 (1988) 2521-2524.

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