Substituted di-t-butylphenols and anti-allergic use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514563, 548253, 548252, 548251, 562452, 562453, 562455, 562457, C07C10385, C07D25704, A61K 3141, A61K 31165

Patent

active

050495720

ABSTRACT:
Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.

REFERENCES:
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patent: 4153728 (1979-05-01), Wolff et al.
patent: 4322439 (1982-03-01), Klemm et al.
patent: 4710515 (1987-12-01), Kirk et al.
patent: 4714776 (1987-12-01), Bell et al.
patent: 4716178 (1987-12-01), Scherrer
Chemical Abstracts, 69, 58954e (1968).
Chemical Abstracts, 72, 68160u (1970).

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