Method for preventing or treating symptoms resulting from closed

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514422, 514423, A61K 31675, A61K 3140

Patent

active

050495534

ABSTRACT:
A method is provided for preventing onset of or treating symptoms resulting from closed head injuries, in hypertensive or normotensive patients, by administering an ACE inhibitor, for example captopril, zofenopril, fosinopril, ceranapril, enalapril or lisinopril.

REFERENCES:
patent: 4906614 (1990-03-01), Giertz et al.
Deicken, Biol. Psychiatry, 1986, 21:1425-28.
Germain et al., Biol. Psychiatry, 1988, 23:637-641.
Zubenko, Am. J. Psychiatry, 141:110-111 (1984).
Medical Tribune, vol. 29, No. 28, Thurs., Oct. 13, 1988.
Therapy Review, Drug Therapy of Hypertensive Crises, J. L. Stumpf, Clinical Pharmacy, vol. 7, Aug. 1988, pp. 582-591.
Sudilovsky et al, "Captopril Delays Extinction of Conditioned Avoidance Response in the Rat," Poster Presentation, 14th Congress of the Collegium Internationale Neuro-Psychopharmacologicum, Florence, Jun. 1984 (Abstracts, CINP, 1984, 397).

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