Process for the preparation of hydroxybenzaldehydes

Details Process for the preparation of hydroxybenzaldehydes Process for the preparation of hydroxybenzaldehydes

1984-11-13

1986-04-22

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568437, C07C 4545

Patent

active

045844100

ABSTRACT:
In a Reimer-Tiemann reaction for the preparation of a mixture of two hydroxybenzaldehydes (i.e., salicylaldehyde and p-hydroxybenzaldehyde) by reacting phenol with chloroform and an aqueous alkali solution in a heterogeneous system, the two hydroxybenzaldehydes can be prepared in a controlled formation ratio, yield and reaction rate depending upon the conditions used when the reaction is carried out in the presence of a phase transfer catalyst selected from the group consisting of a cationic type phase transfer catalyst, an amphoteric type phase transfer catalyst and an anionic type phase transfer catalyst.

REFERENCES:
Brady et al., Jour. Chem. Soc. (London) (1950), 767-777.
Wynberg, Chemical Reviews (1960), vol. 60, 169-170.
Hiyama et al., Tetrahedron (1974), vol. 30, 2661, 2664-2668.
Merck Index (1983), 10th Ed., 1981.

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