Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(

Details Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2( Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(

1985-05-23

1986-04-22

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560256, C07D30910

Patent

active

045843899

ABSTRACT:
The compound 6(R)-[2-8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6, 7,8,8a(S)-decahydronaphthyl-1(S)ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-p yran-2-one is prepared in two steps from mevinolin and comprise reduction of the two double bonds and C-methylation of the 8(S)-(2-methylbutyryloxy) group to form the 2,2-dimethylbutyryloxy group. The two steps can be performed in either order.

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