Small particle aerosol liposome and liposome-drug combinations f

Details Small particle aerosol liposome and liposome-drug combinations f Small particle aerosol liposome and liposome-drug combinations f

1989-07-21

1991-09-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 43, 4284022, 264 4, 264 41, A61K 3722

Patent

active

050493884

ABSTRACT:
Disclosed are aqueous aerosol droplets containing liposome or interacted liposome-drug or medication combination particles in a continuous phase of air or oxygen-enriched air advantageous for the treatment of a wide variety of diseases. The drug or medication is interacted with the liposome membrane so that on its rupture the drug or medication is not lost from the liposome. Different methods of preparation of the aerosol particles containing the liposome and interacted liposome-drug combination particles are described which can be used in small particle aerosol treatment. The majority of the aerosol droplets containing the liposome particles alone or with drugs has a diameter less than 5 microns and has an aerodynamic mass median diameter ranging from about 1 to 3 microns, and the liposome and interacted-liposome drug particles are substantially uniform in size and less than 1 micron in diameter.

REFERENCES:
patent: 4438052 (1984-03-01), Weder et al.
Chemical Abstracts, 103:27287f (1985), McGurk et al.
Chemical Abstracts, 105:197191d (1986), McGurk.

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