Substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, the

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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560 51, C07C 5986

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active

047540613

ABSTRACT:
The invention relates to novel substituted (2,3-dihydro-1-oxo-1H-inden-5-yl)alkanoic acids, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

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Cragoe, E. J., Jr., J. Med. Chem., 1982, 25 567-579.
O. W. Woltersdorf, et al., J. Med. Chem., 20 1400 (1977).
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Seminars in Neurological Surgery, Neural Traums L. F. Marshall et al., 347-351, (1979).
H. K. Kimelberg et al., Brain Res. 105, (1976), 309-323.
H. K. Kimelberg, Rasin Res. 13 111, (1979).
H. K. Kimelberg et al. 177 (1979) 533.

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