Hypoglycemic 5-substituted oxazolidine-2,4-diones

Details Hypoglycemic 5-substituted oxazolidine-2,4-diones Hypoglycemic 5-substituted oxazolidine-2,4-diones

1987-05-28

1988-06-28

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514367, 514374, 514375, 514376, 548180, 548204, 548205, 548217, 548226, 548232, A61K 3142, A61K 31425, C07D26334, C07D27732

Patent

active

047539569

ABSTRACT:
Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.

REFERENCES:
patent: 2338220 (1944-01-01), Wallingford
patent: 2721197 (1955-08-01), Sheehan
patent: 2961377 (1960-11-01), Shapiro
patent: 3699229 (1972-10-01), Plotnikoff
patent: 4220787 (1980-09-01), Scholz
Burger's Medicinal Chemistry, 4th ed., Pt. II (1979: John Wiley and Sons, New York) pp. 1056-1080.
Ciamacian and Silber, Ber. 19, pp. 1708-1714 (1886).
Clark-Lewis, Chem. Rev. 58, pp. 63-99 (1958).
Brink and Freeman, J. Neuro. Chem. 19 (7), pp. 1783-1788 (1972).

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