Enhancing platelet morphology prior to patient use

Details Enhancing platelet morphology prior to patient use Enhancing platelet morphology prior to patient use

1987-06-24

1988-06-28

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435 2, A61K 3514

Patent

active

047537973

ABSTRACT:
Platelet morphology in platelet concentrates is significantly enhanced by subjecting the platelets to a gentle heating step. Platelets heated at 37.degree. C. for one hour have at least a 25% increase in the number of disc-like forms over non-heated platelets. When subsequently infused in a patient, the treated platelets show a one hour post-infusion platelet corrected count increment of about 70% higher than non-heated control platelets.

REFERENCES:
Han et al--Chem. Abst. vol. 81 (1974), p. 117, 881b.
Ogston et al--Chem. Abst., vol. 94 (1981), p. 100 588g.
Ogston et al., J. Physiol., vol. 310 (1981), pp. 71p-72p.
Han et al., Brit. J. Haematology, vol. 26 (1974), pp. 373-389.

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