Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-07-22
2000-05-30
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
060691557
ABSTRACT:
A method of anesthetizing a human patient prior to major surgery, which comprises the administration to the patient of at least 200 mg levobupivacaine.
REFERENCES:
patent: 4695576 (1987-09-01), Ekenstam et al.
Butterworth, J.F. (1993) Bupivacaine Inhibits Cyclic-3', 5'-Adenosine Monophosphate Production. Anesthesiology 79: 88-95.
Mazoit, J.X. et al. (1993) Myocardial Uptake of Bupivacaine: II. Pharmacokinetics and Pharmacodynamics of Bupivacaine Enantiomers in the Isolated Perfused Rabbit Heart. Anesth. Analg. 77(3): 477-482.
Clarkson, C.W., L.M. Hondeghem (1985) Mechanism for Bupivacaine Depression of Cardiac Conduction: Fast Block of Sodium Channels during the Action Potential with Slow Recovery from Block during Diastole. Anesthesiology 62: 396-405.
Courtney, K.R., J.J. Kendig (1988) Bupivacaine is an effective potassium channel blocker in heart. Biochimica et Biophysica Acta 939: 163-166.
Denson, D.D., M.M. Behbehani, R.V. Gregg (1992) Enantiomer-Specific Effects of an Intravenously Administered Arrhythymogenic Dose of Bupivacaine on Neurons of the Nucleus Tractus Solitarius and the Cardiovascular System in the Anesthetized Rat. Regional Anesthesia 17(6): 311-316.
Vanhoutte, F., et al. (1991) Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle. Br. J. Pharmacol. 103: 1275-1281.
Valenzuela, C. et al. (1994) Stereoselective Bupivacaine Block of the Human Cardiac Delayed Rectifier Kv1.5 Channel. Biophys. J. 66: A205; abstract No. Tu-Pos383.
Aps, C., F. Reynolds (1978) An Intradermal Study of the Local Anaesthetic and Vascular Effects of the Isomers of Bupivacaine. Br. J. Clin. Pharmac. 6: 63-68.
Burm, A.G.L. et al. (1994) Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate. Br. J. Clin. Pharmac. 38: 125-129.
Reynolds, F. (1995) In defence of bupivacaine. International Journal of Obstetric Anesthesia 4(2): 93-108.
Rutten, A.J. et al. (1993) Tissue Distribution of Bupivacaine Enantiomers in Sheep. Chirality 5(7): 485-491.
Aberg, G. (1972) Toxicological and Local Anaesthetic Effects of Optically Active Isomers of Two Local Anaesthetic Compounds. Acta Pharmacologica Et Toxicologica 31: 273-286.
Testa, B., W.F. Trager (1990) Racemates Versus Enantiomers in Drug Development: Dogmatism or Pragmatism? Chirality 2: 129-133.
Ariens, E.J. (1991) Racemic therapeutics--ethical and regulatory aspects. Eur. J. Clin. Pharmacol. 41(2): 89-93.
Rutten, A.J., L.E. Mather, C.F. McLean (1991) Cardiovascular Effects and Regional Clearances of I.V. Bupivacaine in Sheep: Enantiomeric Analysis. Br. J. Anaesthesia 67: 247-256.
Luduena, F.P., E.F. Bogado, B.F. Tullar (1972) Optical Isomers of Mepivacaine and Bupivacaine. Arch. Int. Pharmacodyn. 200(2): 359-369.
Rutten, A.J. et al. (1992) Postoperative course of plasma protein binding of lignocaine, ropivacaine and bupivacaine in sheep. J. Pharm. Pharmacol. 44: 355-358.
Lee-Son, S. et al. (1992) Stereoselective Inhibition of Neuronal Sodium Channels by Local Anesthetics. Anesthesiology 77(2): 324-335.
Wang, G.K. et al. (1992) Altered Stereoselectivity of Cocaine and Bupivacaine Isomers in Normal and Batrachotoxin-modified Na+ channels. J. Gen. Physiol. 100(6): 1003-1020.
Luduena, F.P., B.F. Tullar (1970) Optical isomers of an aminoacyl xylidide. Chemical Abstracts 73(5); abstract No. 25314a.
Clark, B.J., A. Hamdi (1991) Reversed-phase and chiral high-performance liquid chromatographic assay of bupivacaine and its enantiomers in clinical samples after continuous extraplural infusion. Journal of Chromatography 553: 383-390.
Ariens, E.J. (1990) Stereoselectivity in pharmacodynamics and pharmacokinetics. Schweiz. Med. Wochenschr. 120(5): 131-134.
Gristwood, R. et al. (1994) Reduced cardiotoxicity of levobupivacaine compared with racemic bupivacaine (Marcaine): new clinical evidence. Exp. Opin. Invest. Drugs 3(11): 1209-1212.
Albright, G.A. (1979) Cardiac Arrest Following Regional Anesthesia with Etidocaine or Bupivacaine. Anesthesiology 51: 285-287.
Prentiss, J.E. (1979) Cardiac Arrest Following Caudal Anesthesia. Anesthesiology 50(1): 51-53.
Moore, D.C. et al. (1976) Arterial and Venous Plasma Levels of Bupivacaine Following Epidural and Intercostal Nerve Blocks. Anesthesiology 45(1): 39-45.
Moore, D.C. et al. (1976) Arterial and Venous Plasma Levels of Bupivacaine Following Peripheral Nerve Blocks. Anesthesia and Analgesia . . . Current Researches 55(6): 763-768.
Moore, D.C. et al. (1977) Bupivacaine (Marcaine): An Evaluation of its Tissue and Systemic Toxicity in Humans. Acta Anesth. Scand. 21: 109-121.
Kuhnert, B.R. et al. (1981) Bupivacaine disposition in mother, fetus and neonate. Federation Proceedings 40(31): 684.
Rowland, M., T.N. Tozer, eds. (1995) Clinical Pharmacokinetics Concepts and Applications; Williams & Wilkins; (Chapter 7): 83-88.
Mather, L.E. (1991) Disposition of Mepivacaine and Bupivacaine Enantiomers in Sheep. British Journal of Anaesthesia 67: 239-246.
DuPen, S.L. et al. (1992) Chronic epidural bupivacaine--opioid infusion in intractable cancer pain. Pain 49: 293-300.
Honerjager, P. (1986) The contribution of Na channel block to the negative inotropic effect of antiarrhythmic drugs. Basic Res. Cardiol. 81(Suppl 1): 33-37.
Fozzard, H.A., J.A. Wasserstrom (1985) Voltage Dependence of Intracellular Sodium and Control of Contraction. In Zipes D.P., E. Jalife (eds) Grune & Stratton, Orlando; 51-57.
Schlepper, M. (1989) Cardiodepressive effects of antiarrhythmic drugs. European Heart Journal 10(Suppl E): 73-80.
Reiz, S., S. Nath (1986) Cardiotoxicity of Local Anaesthetic Agents. Br. J. Anaesth. 58: 736-746.
DeJong, R.H., N.L. Davis (1981) Treating Bupivacaine Arrhythmias. Reg. Anesth. 6: 99-103.
Strichartz, G.R. (1988) Neural physiology and local anesthetic action. In: Neural Blockade In Clinical Anesthesia and Management of Pain, Cousins, M.J., P.O. Bridenbaugh (eds), J B Lippincott Company, Philadelphia; 25-45.
Mather Laurence E.
McGlashan Richards Andrew John
Darwin Discovery Ltd.
Spivack Phyllis G.
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