Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-02-12
2000-05-30
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514256, 514373, 546114, 546157, 546243, A01N 4358, A61K 31505, C07D51502, C07D21516, C07D21136
Patent
active
060691441
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to N-heterocyclic compounds of the general formula I ##STR3## and to their salts and N-oxides, where the variables have the following meanings: ##STR4## where the groups R.sup.1 to R.sup.26 independently of one another are: hydrogen, cyano, nitro, halogen, aminocarbonyl, methylsulfonyl, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, (C.sub.1 -C.sub.4 -alkoxy)carbonyl, aryl, aryloxy or hetaryl, it being possible for the aryl and hetaryl rings to be unsubstituted or to have attached to them one to three groups, in each case selected from amongst: cyano, nitro, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, (C.sub.1 -C.sub.4 -alkoxy)carbonyl and C.sub.1 -C.sub.4 -acyl; hydrogen atoms of these chains to be replaced independently of one another by one of the following groups: -alkenyl, C.sub.2 -C.sub.8 -haloalkenyl or C.sub.2 -C.sub.8 -alkynyl, it being possible for each of these 5 radicals additionally to have attached to them one to three groups, in each case selected from amongst: cyano, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, (C.sub.1 -C.sub.4 -alkoxy)carbonyl, C.sub.3 -C.sub.7 -cycloalkyl and C.sub.5 -C.sub.7 -cycloalkenyl; possible for these radicals to be partially or fully halogenated or to have attached to them one to three groups, in each case selected from amongst: cyano, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl and C.sub.1 -C.sub.4 -alkoxy; -C.sub.8 -alkyl or C.sub.3 -C.sub.7 -cycloalkyl; or to have attached to them one to three groups, in each case selected from amongst: cyano, nitro, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, (C.sub.1 -C.sub.4 -alkoxy)carbonyl, C.sub.1 -C.sub.4 -acyl, C.sub.1 -C.sub.4 -alkylsulfynyl, C.sub.1 -C.sub.4 -alkylsulfonyl, aryl, aryloxy and hetaryl, it being possible for these aryl and hetaryl rings, in turn, additionally to have attached to them one to three substituents, in each case selected from amongst: cyano, nitro, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, (C.sub.1 -C.sub.4 -alkoxy)carbonyl and C.sub.1 -C.sub.4 -acyl; C.sub.3 -C.sub.7 -cycloalkyl or C.sub.5 -C.sub.7 -cycloalkenyl, it being possible for these rings to be unsubstituted, partially or fully halogenated or to have attached to them one to three groups, in each case selected from amongst: cyano, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, (C.sub.1 -C.sub.4 -alkoxy)carbonyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.5 -C.sub.7 -cycloalkenyl, aryl, aryloxy and hetaryl, it being possible for these aryl and hetaryl rings, in turn, additionally to have attached to them one to three substituents, in each case selected from amongst: cyano, nitro, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, (C.sub.1 -C.sub.4 -alkoxy)carbonyl and C.sub.1 -C.sub.4 -acyl; unsubstituted or to have attached to it one to three groups, in each case selected from amongst: cyano, nitro, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, (C.sub.1 -C.sub.4 -alkoxy)carbonyl, C.sub.1 -C.sub.4 -acyl, aryl, aryloxy a
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Ammermann Eberhard
Eicken Karl
Hamprecht Gerhard
Lamm Gunther
Lorenz Gisela
BASF - Aktiengesellschaft
Shah Mukund J.
Truong Tamthom N.
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