Secreted mac-2-binding glycoprotein

Details Secreted mac-2-binding glycoprotein Secreted mac-2-binding glycoprotein

1995-06-07

2000-05-30

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 691, 4352523, 43525411, 536 235, 530350, 530395, 4241851, 4242771, A61K 3818, C07K 1446

Patent

active

060691271

ABSTRACT:
A purified glycoprotein complex of over 1200 kD apparent native molecular weight having a sedimentation value of approtely 25S and having the ability to selectively bind human Mac-2 or interfere with PHA activation of lymphocytes, DNA sequences that encode the protein, and expression systems for expressing it, thus providing for medicaments that are useful for treating or diagnosing diseases, including cancer, infectious disease, and diseases of the immune system.

REFERENCES:
patent: 5298391 (1994-03-01), Iacobelli
patent: 5492899 (1996-02-01), Masor et al.
Aruffo A; Melnick M B Linsley P S; Seed B. The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. Journal of Experimental Medicine, (Oct. 1, 1991) 174 (4) 949-52.
Linsley P S; Horn D; Marquardt H; Brown J P; Hellstrom I; Hellstrom K E; Ochs V; Tolention E. Identification of a novel protein secreted by lung carcinoma cells. Biochemistry, (May 20, 1986) 25 (10) 2978-86.
Newburg et al. A human milf factor inhibits binding a human immunodefficeincy virus to the CD4 receptor. Pediatric Research 31:22-28, 1992.
Inohara et al. Interactions between galetin-3 and Mac-2-binding protein mediate cell-cell adhesion. Cancer Research, (Oct. 1, 1996), 56(19):4530-4.
Nonaka et al. Detailed characteristic of a high-molecular weight glycoprotein secreted by lung cancer cells. Japanese Journal of Cancer Research, (Sep. 1993), 84(9):982-8.
Rosenberg I.; Cherayil B.J.; Isselbacher K.J.; Pillai S. Mac-2-binding glycoproteins: Putative ligands for a cytosolic .beta.-galactoside lectin. J. Biol. Chem., (1991) 266/28 (18731-18736, Oct. 1991.
Koths et al. Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain. J. Biol. Chem., (Jul. 5, 1993) 268 (19) 45245-9.
Bowie et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science, (Mar. 16, 1990) 247 (4948) 1306-10.

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