Substituted furans as inhibitors of 3-hydroxy-3-methylglutaryl-c

Details Substituted furans as inhibitors of 3-hydroxy-3-methylglutaryl-c Substituted furans as inhibitors of 3-hydroxy-3-methylglutaryl-c

Filed on

1987-08-05

Date issued

1988-12-20

Examiner

Hollrah, Glennon H.

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Heterocyclic carbon compounds containing a hetero ring...

Other Related Categories

549472, 549496, 549501, C07D30930, C07D30734

Type

Patent

Status

active

Patent number

047926147

Description

ABSTRACT:
Compounds of the formula: ##STR1## in which ##STR2## where M is hydrogen or alkyl; one of R.sup.2 and R.sup.3 is phenyl or substituted phenyl where the substituent is alkyl, alkoxy, halogen, trifluoromethyl, nitro, amino, cyano or carboxyl; and the other of R.sup.2 and R.sup.3 is hydrogen, alkyl, or a halogen; or a pharmaceutically acceptable salt thereof, are HMG--CoA reductase inhibitors useful in the treatment of atherosclerosis, hypercholesterolaemia, hyperlipaemia and similar disease states characterized by elevated cholesterol levels in the blood.

REFERENCES:
patent: 4375475 (1983-03-01), Willard et al.
patent: 4571428 (1986-02-01), Kapa
patent: 4613610 (1986-09-01), Wareing
patent: 4654363 (1987-03-01), Prugh
Hoffman et al., "3-Hydroxy-3-Methylglutaryl, etc" J. Med Chem, 29 159 (1986).
Derwent 84-201398/32 (Abstract of WO 8402-903.
Rosen et al., J. Am. Chem. Soc. 107, 3731 (1985).
Sletzinger et al., Tetrahedron Letters 26, 2951 (1985).
Stokker et al., J. Med. Chem. 28, 347 (1985).
Stokker et al., J. Med. Chem. 29, 170 (1986).

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