Immunoassay of free kappa light chains for the detection of mult

Details Immunoassay of free kappa light chains for the detection of mult Immunoassay of free kappa light chains for the detection of mult

1985-10-18

1988-12-20

Naff, David M.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

436545, 436811, G01N 33534, G01N 3353, G01N 3368

Patent

active

047925299

ABSTRACT:
Multiple sclerosis (MS) is diagnosed by determining with a quantitative immunoassay the quantity of free kappa light chains in the cerebrospinal fluid of a patient. The immunoassay is preferably a radioimmunoassay. In carrying out the immunoassay, the free kappa light chains are combined with antiserum specific thereto. This method of diagnosing MS has high sensitivity in distinguishing between normal patients and patients affected with MS.

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