Method of identifying molecules that home to a selected organ in

Details Method of identifying molecules that home to a selected organ in Method of identifying molecules that home to a selected organ in

1997-06-23

2000-05-30

Priebe, Scott D.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

4241921, 4241931, 435 6, A61K 4900, C12Q 168

Patent

active

060688297

ABSTRACT:
The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ.

REFERENCES:
patent: 5081034 (1992-01-01), Bevilasqua et al.
patent: 5098833 (1992-03-01), Lasky et al.
patent: 5216131 (1993-06-01), Lasky et al.
patent: 5225538 (1993-07-01), Capon et al.
patent: 5270163 (1993-12-01), Gold et al.
patent: 5288846 (1994-02-01), Quertermous et al.
patent: 5304640 (1994-04-01), Lasky et al.
patent: 5415874 (1995-05-01), Bender et al.
patent: 5428130 (1995-06-01), Capon et al.
patent: 5453362 (1995-09-01), Lamarco et al.
patent: 5506126 (1996-04-01), Seed et al.
patent: 5688935 (1997-11-01), Stephans et al.
Baillie et al., "Tumour Vasculatur--A Potential Therapeutic Target" British J. Cancer 72:257-267 (1995).
Burinoni et al., "Recombinant Human Fab to Glycoprotein D Neutralizes Infectivity and Prevents Cell-to-Cell Transmission of Herpes Simplex Viruses 1 and 2 In Vitro," Proc. Natl. Acad. Sci. USA 91:355-359 (1994).
Burrows and Thorpe, "Vascular Targeting--A New Approach to the Therapy of Solid Tumors," Pharmac. Ther. 64:155-174 (1994).
Burton et al., "A Large Array of Human Monoclonal Antibodies to Type 1 Human Immunodeficiency Virus From Combinatorial Libraries of Asymptomatic Seropositive Individuals," Proc. Natl. Acad. Sci. USA 88:10134-10137 (1991).
Cattani et al., "Cloning and Characterization of Human Recombinant Antibody Fab Fragments Specific for Types 1 and 2 Herpes Simplex Virus, " Chem. Abstr. Immunochemistry 123:141201m (1995).)
Cattani et al., "Cloning and Characterization of Human Recombinant Antibody Fab Fragments Specific for Types 1 and 2 Herpes Simplex Virus," Microbiologica 18:135-142 (1995).
Davis et al., "Use of a High Affinity DNA Ligand in Flow Cytometry, " Nucl. Acids Res. 24:702-706 (1996).
Drolet et al., "An Enzyme-linked Oligonucleotide Assay," Nat. Biotech. 14:1021-1025 (1996).
Dvorak et al., "Structure of Solid Tumors and Their Vasculature: Implications for Therapy with Monoclonal Antibodies," Cancer Cells 3:77-85 (1991).
Goetz et al., "Lu-ECAM-1-Mediated Adhesion of Melanoma Cells to Endothelium Under Conditions of Flow," Int. J. Cancer 65:192-199 (1996).
Gold et al., "Diversity of Oligonucleotide Functions," Annu. Rev. Biochem. 64:763-797 (1995).
Goodson et al., "High-affinity Urokinase Receptor Antagonists Identified with Bacteriophage Peptide Display," Proc. Natl. Acad. Sci. USA. 91:7129-7133 (1994).
Hicke et al., "DNA Aptamers Block L-Selectin Function In Vivo," J. Clin. Invest. 98:2688-2692 (1996).
Huang et al., "Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature," Science 275:547-550 (1997).
Lappi, Douglas A., "Tumor Targeting Through Fibroblast Growth Factor Receptors," Cancer Biology 6:279-288 (1995).
Leff, D., "NeXstar Previews `Pass ` for Downstream Synthesis of Therapeutic Oligos, " Bioworld Today. 8:2&4 (1997).
Martiny-Baron and Marme, "VEGF-mediated Tumour Angiogenesis: A New Target for Cancer Therapy," Current Biology 6:675-680 (1995).
Miner et al., "Clonal Drift of Cell surface, Melanogenic, and Experimental Metastatic Properties of in vivo-selected, Brain Meninges-colonizing Murine B16 melanoa," Cancer Research 42:4631-4638(1982).
Pasqualini and Ruoslahti, "Organ Targeting in vivo Using Phage Display Peptide Libraries," Nature 380:364-366 (1996).
Pauli et al., "Organ-preference of Metastasis," Cancer and Metastasis Reviews 9:175-189 (1990).
Zhu et al., "Mediation of Lung Metastasis of Murine Melanomas by a Lung-specific Endothelial cell Adhesion Molecule," Proc. Natl. Acad. 88:9568-9572 (1991).
Hendrikx et al., "Homing of Fluuroescently Labeled Murine Hematopoietic Stem Cells," Expt. Hematol. 24:129-140 (1996).
Pasqualini et al., ".alpha..nu. Integrins as Receptors for Tumor Targeting by Circulating Ligands, " Nature Biotechnol.15:542-548 (1997).

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