Method of preventing or delaying the onset and progression of Al

Details Method of preventing or delaying the onset and progression of Al Method of preventing or delaying the onset and progression of Al

1997-04-14

2000-02-15

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514159, 514162, 514165, 5142265, 514356, 514357, 514365, 514370, 514375, 514400, 514404, 514419, 514420, 514423, 514428, 514429, 514448, 514471, 514567, 514569, A61K 3160, A61K 31615, A61K 3154, A61K 3144, A61K 31425, A61K 3142, A61K 31415, A61K 3140, A61K 3138, A61K 3134, A61K 31195, A61K 3119

Patent

active

060253959

ABSTRACT:
The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The invention also relates to a method of treating Alzheimer's disease and related neurodegenerative disorders so as to ameliorate the further progress of symptoms. The methods involve the administration of a non-steroidal anti-inflammatory agent and/or a histamine H2 receptor blocking agent. According to indication, the present method can be applied to individuals who are currently asymptomatic but at risk of developing Alzheimer's disease, to individuals who have mild cognitive symptoms that may either denote an incipient prodrome of Alzheimer's disease or represent early symptoms (prodromal stage), or to individuals who have a clinical diagnosis of Alzheimer's disease.

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CA 113:17731, Yanagawa et al, 1990.
Breitner et al, "Delayed Onset of Alzheimer's Disease With Nonsteroidal Anti-Inflammatory and Histamine H2 Blocking Drugs", Neurobiology of Aging 16(4):523-530 (1995).
McGeer et al, Anti-inflammatory drugs and Alzheimer's disease, The Lancet 335:1037 (1990).
Schnabel, J., "New Alzheimer's Therapy Suggested", Science 260:1719 (1993).
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