substituted tetrahydrofuran analogs of prostaglandins as ocular

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

549475, 549497, 549504, A61K 3134, C07D30720

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active

060253924

ABSTRACT:
Substituted tetrahydrofuran analogs of F-series prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.

REFERENCES:
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patent: 5574066 (1996-11-01), Chan et al.
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Kerstetter et al., "Prostaglandin F.sub.2.alpha. -1-Isopropylester Lowers Intracular Pressure Without Decreasing Aqueous Humor Flow" American Journal of Ophthalmology 105:30-34 (1988).
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Verdoorn et al., "Synthesis of Methyl (5Z,13E)(15S)-9.alpha.-acetoxy-15-hydroxy-17-(3-trifluoromethylphenyl)-11- oxa-18,19,20-trinorprosta-5,13-dienoate" S. Afr. Tydskr. Chem. 40(2):134-138 (1987).
Vlattas et al., "Synthesis of 9-Oxaprostaglandins" Tetrahedron Letters No. 51/52:4455-4458, Pergamon Press, 1974.
Vlattas et al., "Synthesis of 11-Oxaprostaglandins" Tetrahedron Letters No. 51/52:4451-4454, XP000644759, Pergamon Press, 1974.

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