Peptide derivative amphiphatic compound, intermediate thereof an

Details Peptide derivative amphiphatic compound, intermediate thereof an Peptide derivative amphiphatic compound, intermediate thereof an

Filed on

1991-04-08

Date issued

1993-10-12

Examiner

Stoll, Robert L.

Patent Class

Chemistry: natural resins or derivatives; peptides or proteins;

SubClass

Peptides of 3 to 100 amino acid residues

SubSubClass

6 to 7 amino acid residues in defined sequence

Other Related Categories

530331, 530330, 564152, 564159, 564192, 564199, 564201, 564504, 554106, 554112, 554 35, 554 51, 554 56, 554 57, C07K 706, C07C23300, C07C23712

Type

Patent

Status

active

Patent number

052527069

Description

ABSTRACT:
A peptide derivative amphiphatic compound or N-terminal salt thereof represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each represents a straight-chain or branched alkyl or acyl group having 8 to 24 carbon atoms optionally having a substituent or an unsaturated group; X represents --O--or --NH--; R.sup.3n and R.sup.3(n+1) each represents an .alpha.--amino acid side chain; n is an integer of from 0 to 5; the compound may be a racemic compound or an optically active compound when the compound has an asymmetric carbon atom; and the N-terminal salt of the compound optionally forms with an acid component; an intermediate thereof, a liposome comprising said peptide derivative amphiphatic compound and a film consisting of a monolayer or multilayers comprising the peptide derivative amphiphatic compound are disclosed.

REFERENCES:
patent: 2236516 (1941-04-01), Cahn et al.
patent: 3239546 (1966-03-01), Rogier
patent: 4166132 (1979-08-01), Kraska
patent: 4863941 (1989-09-01), Barner
European Search Report.
Chemical Abstracts, vol. 92, 1980, p. 547, abstract No. 93919u, Columbus, Ohio, US; & DE-A-2 820 892 (Nattermann, A., Und Cie. GmbH) Nov. 22, 1979.
Scientific American, vol. 256, No. 1, Jan. 1987, pp. 91-99, New York, US; M. J. Ostro: "Liposomes".
J. Am. Chem Soc., vol. 108, 1986, pp. 487-490; R. Neumann et al: "Peptide Liposomes from amphiphilic amino acids".
Patent Abstracts of Japan, vol. 12, No. 202 (C-503) [3049], Jun. 10, 1988; JP-A-63 2921 (Yamanouchi Pharmaceut. Co., Ltd.) Jan. 7, 1988, corresponding to JP-A-61-144062.

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