Polynucleotides encoding human G-protein chemokine receptor HDGN

Details Polynucleotides encoding human G-protein chemokine receptor HDGN Polynucleotides encoding human G-protein chemokine receptor HDGN

1995-06-06

2000-02-15

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 435325, 435361, 536 235, 536 243, 536 244, 536 2372, 536 2433, C12N 1509, C12N 1500, C07K 14715

Patent

active

060251549

ABSTRACT:
Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

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