Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1991-10-28
2000-02-15
Fredman, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 243, 536 2432, 536 266, C12Q 168, C12P 1934, C07H 2102, C07H 2104
Patent
active
060251263
ABSTRACT:
This invention relates generally to methods and compositions for direct detection of specific nucleic acid flanking sequences associated with structural chromosomal aberration breakpoints, by forming hybrids between the sequences and genetic probes, and detecting the probes. In particular aspects, the invention concerns detection of nucleic acid sequences in situ in chromosomes, and more specifically in cells, including interphase cells. Compositions of probes useful for detecting chromosomal translocations, in particular those associated with human leukemias, are also disclosed. An aspect of the invention is labelled probes that, when juxtaposed by formation of an aberration, are distinguishable and provide a pattern different from that of normal cells.
REFERENCES:
patent: 4559305 (1985-12-01), Witte et al.
patent: 4681840 (1987-07-01), Stephenson et al.
patent: 5057410 (1991-10-01), Kawasaki et al.
Tkachuk et al. Science, 250:559-562, 1990.
Anastasi et al., Am. J. Pathol., 136(1):131-139, 1990.
Gray et al., Bone Marrow Transplantation, 6:14-19, 1990.
Grossman et al., Am. J. Hum. Genet., 45:729-738, 1989.
Hutchins et al., Aust. N.Z. J. Med., 19:443-448, 1989.
Westbrook, Blood Reviews, 2:1-8, 1988.
Blennerhassett et al., Leukaemia, 2(10):648-657, 1988.
Bartram et al., Blut, 55:505-511, 1987.
Benn et al., Cancer Genet Cytogenet., 29:1-7, 1987.
Westbrook et al., PNAS, 82:8742-8746, 1985.
Trask et al., Hum. Genet., 78(3):251-259, 1988.
Pinkel et al., PNAS, 83(9):2934-2938, 1986.
Rubin et al, "Heterogeneity of genomic fusion of BCR and ABL in philadelphia chromosome-positive acute lymphoblastic leukemia", Proc. Natl. Acad. Sci. 85:2795-2799, Apr. 1988.
Bartram et al. Blut 55: 505-511, 1987.
Biennerhassett et al. Leukemia 2: 648-657, 1988.
ARCH Development Corporation
Fredman Jeffrey
LandOfFree
Methods and compositions for the detection of chromosomal aberra does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for the detection of chromosomal aberra, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the detection of chromosomal aberra will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1904676