Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From carboxylic acid or derivative thereof
Patent
1988-01-11
1989-12-19
Kight, John
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
From carboxylic acid or derivative thereof
528296, 528297, 528302, 528303, 523113, 424 78, 424425, C08G 6302
Patent
active
048884138
ABSTRACT:
The present invention are highly reproducible poly(propylene glycol fumarate) compositions having a controlled end group ratio and range of molecular weights with minimal low molecular weight and excessively high molecular weight fractions, and methods for their manufacture. These compositions, having a preferred weight average molecular weight (Mw) of between about 500 and 3000 and a number average molecular weight (Mn) of between about 300 and 2000, are especially useful in biomedical applications such as in bone cements and tissue implants or glues. In the preferred embodiment, the polymer is prepared from propylene glycol (PG) and fumaric acid (FA) by one of three methods: melt polymerization using non-volatile starting materials; step polymerization where in each step the polymer is increased by the addition of two groups to the polymer ends; or under reaction conditions maintained so that only the condensation byproduct, water, is removed during the reaction, thereby keeping the ratio between PG and FA constant. Variations of the PPF polymers include polymers with increased sensitivity to hydrolysis through incorporation of lactic acid groups into the polymer and polymers formed from maleic acid, maleic anhydride, citraconic acid or citraconic anhydride.
REFERENCES:
patent: 3978203 (1976-08-01), Wise
patent: 4080969 (1978-03-01), Casey et al.
patent: 4722948 (1988-02-01), Sanderson
Acquah S. A.
Kight John
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