Inductive collagen-based bone repair preparations

Details Inductive collagen-based bone repair preparations Inductive collagen-based bone repair preparations

1987-09-25

1989-12-19

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Processes of preparing a desired or intentional composition...

424423, 424 95, 623 16, 606 76, A61F 202, A61F 504

Patent

active

048883662

ABSTRACT:
An improved process for the preparation of mineral/collagen/OF (osteogenic factor) inductive implants for bone repair utilizes drying, under ambient pressure conditions, a suspension of 75-95% mineral particles, 5-25% collagen, and an effective amount of OF, such as 0.5-4% partially purified OFE or its equivalent wherein the concentration of collagen in the suspension subjected to drying is 30-100 mg/ml. The resulting implants are improved. They are homogeneous in composition and have a high compressive modulus as well as containing OF in a biologically active and available form.

REFERENCES:
patent: 4294753 (1981-10-01), Urist
patent: 4394370 (1983-07-01), Jefferies
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4440750 (1984-04-01), Glowacki et al.
patent: 4596574 (1986-06-01), Urist
Urist et al, "Purification of Bovine Bone Morphogenetic Protein by Hydroxy-Apatite Chromatography", Proc. Natl. Acad. Sci. USA, Jan. 1984, vol. 81, pp. 371-375.
Termine et al, "Mineral and Collagen-Binding Proteins of Fetal Calf Bone", J. Biol. Chem., vol. 256, No. 20, Oct. 25, 1981, pp. 10403-10408.

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