Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-12-22
1989-12-19
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142312, 5142395, 514255, 514319, 544166, 544400, 544402, 546205, 546206, 548568, 564168, 564172, 564173, A61K 3140, A61K 3116, C07C10375, C07D20709
Patent
active
048883557
ABSTRACT:
A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms possible of compounds of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, and alkyl and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, one of A and B being ##STR2## and the other being ##STR3## R is hydrogen or alkyl of 1 to 5 carbon atoms, Z is --(CH.sub.2).sub.n -- or branched alkylene of 2 to 8 carbon atoms, n is an integer from 0 to 5, Y is selected from the group consisting of naphthyl, indenyl, heterobicyclics and heteromonocyclic containing 5 to 6 ring members, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, halogen, --OH, --CF.sub.3, --NO.sub.2, --NH.sub.2, monoalkylamino and dialkylamino of 1 to 4 alkyl carbon atoms and phenyl optionally substituted with at least one member of the group consisting of halogen and alkyl and alkoxy of 1 to 4 carbon atoms, R.sub.3 and R.sub.4 are individually hydrogen or alkyl of 1 to 5 carbon atoms or taken together with the nitrogen form a heterocyclic of 5 to 6 ring members and optionally containing --O--, --S-- or nitrogen in the ring and their non-toxic, pharmaceutically acceptable acid addition salts having central analgesic and antiarythmic activity among other activities.
REFERENCES:
patent: 3923813 (1975-12-01), Vanhoof
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4359476 (1982-11-01), Kaplan
patent: 4438130 (1984-03-01), Kaplan
Clemence Francois
Delevallee Francoise
Fortin Michel
Le Martret Odile
Roussel Uclaf
Shah Mukund J.
Tsung Frederick F.
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