New acyl-1H-1,2,4-triazole derivatives

Details New acyl-1H-1,2,4-triazole derivatives New acyl-1H-1,2,4-triazole derivatives

1986-10-03

1989-12-19

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514383, A61K 31075, A61K 3110

Patent

active

048883506

ABSTRACT:
New acyl -1H-1,2,4-triazole derivatives of the formula ##STR1## wherein R may be located on one of the two adjacent nitrogen atoms and may represent hydrogen; a group R.sub.5 -CO wherein R.sub.5 is selected from (C.sub.1-4)alkyl, (C.sub.2-4)alkenyl, (C.sub.2-4)alkynyl, phenyl, phenyl substituted by one to three groups independently selected from halo, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, trifluoromethyl, cyano, nitro, amino, di-(C.sub.1-4)alkylamino, (C.sub.2-4)acylamino and methylenedioxy, benzyl, cinnamyl, amino, (C.sub.1-4)alkylamino, di-(C.sub.1 -C.sub.4)alkylamino, phenylamino, phenylamino wherein the phenyl ring may be substituted by one to three groups independently selected from halo, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, trifluoromethyl, cyano, nitro, amino, di-(C.sub.1-4)alkylamino, (C.sub.2-4)acylamino and methylendioxy, halo(C.sub.1-4)alkyl, (C.sub.1-4)alkoxy and benzyloxy; a group R.sub.6 -SO.sub.2 wherein R.sub.6 may represent (C.sub.1-4)alkyl, phenyl, phenyl substituted by a radical selected from (C.sub.1-4)alkyl and (C.sub.1-4)alkoxy, or phenactyl;

REFERENCES:
patent: 4007276 (1977-02-01), Sale et al.
patent: 4154841 (1979-05-01), Wade et al.
patent: 4154843 (1979-05-01), Wade et al.
patent: 4169148 (1979-09-01), Wade et al.
patent: 4316932 (1982-02-01), Kranz et al.
patent: 4409388 (1983-10-01), Omodei-Sale et al.
patent: 4459302 (1984-07-01), Omodei-Sale et al.

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