Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(

Details Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2( Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(

1995-06-07

1996-05-14

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D26106

Patent

active

055169120

ABSTRACT:
A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated.

REFERENCES:
CA 119:72594v Isoxazole ... function. Garvey et al., p. 1064, 1993.

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